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Soley Bayraktar, Ana M. Gonzalez-Angulo, Xiudong Lei, Aman U. Buzdar, Vicente Valero, Amal Melhem-Bertrandt, Henry M. Kuerer, Gabriel N. Hortobagyi, Aysegul A. Sahin and Funda Meric-Bernstam Efficacy of neoadjuvant therapy with trastuzumab concurrent with anthracycline- and nonanthracycline-based regimens for HER2-positive breast cancer Cancer 118

Article first published online: 27 SEP 2011 | DOI: 10.1002/cncr.26555

The type of neoadjuvant systemic therapy (NST) in HER2-positive breast cancer is predictive of pathologic complete response (pCR) rate independent of disease characteristics. Although TCH (docetaxel, carboplatin, and trastuzumab) is active, trastuzumab combined with an anthracycline-based NST shows a higher pCR rate and recurrence-free survival.

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