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Lorraine L. Lipscombe, Hadas D. Fischer, Lingsong Yun, Andrea Gruneir, Peter Austin, Lawrence Paszat, Geoff M. Anderson and Paula A. Rochon Association between tamoxifen treatment and diabetes Cancer 118

Article first published online: 20 SEP 2011 | DOI: 10.1002/cncr.26559

There is evidence that estrogen deficiency may increase the risk of diabetes, which has implications for breast cancer patients being treated with adjuvant hormonal therapy. This population-based nested case-control study from Ontario, Canada, of 14,360 breast cancer survivors aged 66 years or older finds that current tamoxifen treatment is associated with a significant increase in the incidence of diabetes compared with no tamoxifen treatment (adjusted odds ratio, 1.24; 95% confidence interval, 1.08-1.42; P = .002).

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