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Woo-Young Kim, Ludmila Prudkin, Lei Feng, Edward S. Kim, Bryan Hennessy, Ju-Seog Lee, J. Jack Lee, Bonnie Glisson, Scott M. Lippman, Ignacio I. Wistuba, Waun Ki Hong and Ho-Young Lee Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors Cancer 118

Version of Record online: 22 FEB 2012 | DOI: 10.1002/cncr.26656

This study provides evidence for the first time that the mutation status of both epidermal growth factor receptor (EGFR) and K-Ras could be a predictive marker for response to insulinlike growth factor 1 receptor (IGF-1R) tyrosine kinase inhibitors (TKIs). Also, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase antagonism can abrogate primary resistance of nonsmall cell lung cancer to IGF-1R TKIs.

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