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Katherine Warren, Robyn Bent, Pamela L. Wolters, Alisa Prager, Ryan Hanson, Roger Packer, Joanna Shih and Kevin Camphausen A phase 2 study of pegylated interferon α-2b (PEG-Intron®) in children with diffuse intrinsic pontine glioma Cancer 118

Version of Record online: 15 NOV 2011 | DOI: 10.1002/cncr.26659

The authors present results from a phase 2 study of pegylated interferon α-2b in children with diffuse intrinsic pontine glioma. Although no improvement in 2-year survival is observed compared with an historic cohort, there is a potential increase in the time to disease progression, and the agent is well tolerated. The use of biomarkers for futility is discussed.

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