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Raymond H. Mak, Brian M. Alexander, Kofi Asomaning, Rebecca S. Heist, Chen-yu Liu, Li Su, Rihong Zhai, Marek Ancukiewicz, Brian Napolitano, Andrzej Niemierko, Henning Willers, Noah C. Choi and David C. Christiani A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy Cancer 118

Version of Record online: 5 DEC 2011 | DOI: 10.1002/cncr.26667

This is a candidate gene study examining the association between single-nucleotide polymorphisms in oxidative stress genes and radiation pneumonitis in a retrospective cohort of patients treated with thoracic radiation therapy for lung cancer. There was an association between methylene tetrahydrofolate reductase (MTHFR) genotype and risk of clinically significant radiation pneumonitis.

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