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Xueying Zhao, Xun Wang, Wenting Wu, Zhiqiang Gao, Junjie Wu, David H. Garfield, Haijian Wang, Jiucun Wang, Ji Qian, Huan Li, Li Jin, Qiang Li, Baohui Han, Daru Lu and Chunxue Bai Matrix metalloproteinase-2 polymorphisms and clinical outcome of Chinese patients with nonsmall cell lung cancer treated with first-line, platinum-based chemotherapy Cancer 118

Article first published online: 9 NOV 2011 | DOI: 10.1002/cncr.26669

The authors demonstrate that a genetic variant of matrix metalloproteinase-2, reference polymorphism 12934241 (rs12934241) significantly affects the risk of grade 3 or 4 neutropenia in 663 Chinese patients with advanced nonsmall cell lung cancer receiving first-line, platinum-based regimens. Further stratified analyses reveal that rs12934241 exhibits a much stronger influence on patients receiving cisplatin-gemcitabine regimen than on patients receiving other regimens.

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