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Jiansheng Wang, Jeannelyn S. Estrella, Lan Peng, Asif Rashid, Gauri R. Varadhachary, Hua Wang, Jeffrey E. Lee, Peter W. T. Pisters, Jean-Nicolas Vauthey, Matthew H. Katz, Henry F. Gomez, Douglas B. Evans, James L. Abbruzzese, Jason B. Fleming and Huamin Wang Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation Cancer 118

Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26717

The authors demonstrate that histologic tumor involvement of the resected superior mesenteric vein (SMV)/portal vein (PV) is associated with larger tumor size, higher rates of positive margin, and local/distant recurrence, and is an independent predictor of both disease-free survival and overall survival by multivariate analysis. Complete histologic evaluation of the resected SMV/PV is important for the prognosis in patients with pancreatic adenocarcinoma treated with neoadjuvant therapy and pancreaticoduodenectomy.

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