D. Ross Camidge, Mariana Theodoro, DeLee A. Maxson, Margaret Skokan, Tara O'Brien, Xian Lu, Robert C. Doebele, Anna E. Barón and Marileila Varella-Garcia Correlations between the percentage of tumor cells showing an anaplastic lymphoma kinase (ALK) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization–positive nonsmall cell lung cancer Cancer 118
Version of Record online: 26 JAN 2012 | DOI: 10.1002/cncr.27411
False cellular negatives explain <100% cellular positivity rates in lung cancer positive for ALK (anaplastic lymphoma kinase) as determined by fluorescence in situ hybridization (FISH). Neither percentage of positive cells nor signal copy number predict for benefit from ALK inhibition in ALK FISH–positive tumors.
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