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Ming Yang, Tong Sun, Yifeng Zhou, Li Wang, Li Liu, Xiaojiao Zhang, Xiaohu Tang, Mo Zhou, Pengqun Kuang, Wen Tan, Hui Li, Qipeng Yuan and Dianke Yu The functional cytotoxic T lymphocyte–associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer Cancer 118

Version of Record online: 22 FEB 2012 | DOI: 10.1002/cncr.27455

This study found that the functional cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) 49G-to-A single-nucleotide polymorphism is significantly associated with increased risk of pancreatic cancer, alone and in a multiplicative gene–age, gene–smoking, or gene–drinking interaction manner. Therefore, this functional genetic variation may have tremendous implications for pancreatic cancer and be used for identifying individuals at high risk for developing pancreatic cancer.

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