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Edward A. Monaco III, Amir H. Faraji, Oren Berkowitz, Phillip V. Parry, Uri Hadelsberg, Hideyuki Kano, Ajay Niranjan, Douglas Kondziolka and L. Dade Lunsford Leukoencephalopathy after whole-brain radiation therapy plus radiosurgery versus radiosurgery alone for metastatic lung cancer Cancer 119

Article first published online: 15 JUN 2012 | DOI: 10.1002/cncr.27504

Whole-brain radiation therapy has been associated with neurocognitive dysfunction. Gamma Knife stereotactic radiosurgery as an upfront strategy for management of lung cancer brain metastases avoids white matter changes that have been correlated with whole-brain radiation toxicity.

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