Yingyu Ma, Wei-Dong Yu, Bing Su, Mukund Seshadri, Wei Luo, Donald L. Trump and Candace S. Johnson Regulation of motility, invasion, and metastatic potential of squamous cell carcinoma by 1α,25-dihydroxycholecalciferol Cancer 119
Article first published online: 25 JUL 2012 | DOI: 10.1002/cncr.27531
The active vitamin D metabolite 1α,25-dihydroxycholecalciferol (1,25D3) inhibits squamous cell carcinoma (SCC) cell migration and invasion in vitro and suppresses SCC lung metastasis in vivo. In addition, 1,25D3 promotes the expression of E-cadherin, which contributes to its inhibition of SCC cell motility.
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