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Clara Curiel-Lewandrowski, Susan M. Swetter, Janine G. Einspahr, Chiu-Hsieh Hsu, Ray Nagle, Paul Sagerman, Joseph Tangrea, Howard Parnes, David S. Alberts and Hsiao-Hui Chow Randomized, double-blind, placebo-controlled trial of sulindac in individuals at risk for melanoma Cancer 118

Article first published online: 17 MAY 2012 | DOI: 10.1002/cncr.27540

Exposure to oral sulindac at 150 mg twice a day for 8 weeks in patients with atypical nevi results in measurable levels of sulindac and its metabolites in melanocytic nevi. Sulindac intervention did not result in significant changes in vascular endothelial growth factor A expression but marginally increased the expression of the apoptotic marker cleaved caspase-3 in atypical nevi.

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