Tomofumi Hamada, Masahiro Nomura, Yoshiaki Kamikawa, Norishige Yamada, Surinder K. Batra, Suguru Yonezawa and Kazumasa Sugihara DF3 epitope expression on MUC1 mucin is associated with tumor aggressiveness, subsequent lymph node metastasis, and poor prognosis in patients with oral squamous cell carcinoma Cancer 118
Article first published online: 20 MAR 2012 | DOI: 10.1002/cncr.27542
To the authors' knowledge, the current study is the first to provide clinical evidence that aberrant expression of DF3/MUC1 is an independent prognostic factor indicating poor prognosis in patients with oral squamous cell carcinoma (OSCC). DF3/MUC1 is a risk factor for predicting subsequent lymph node metastasis in patients with OSCC and therefore can influence decisions regarding the need for elective neck dissection.
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