Ibrahim Qaddoumi, Catherine A. Billups, Michael Tagen, Clinton F. Stewart, Jianrong Wu, Kathleen Helton, M. Beth McCarville, Thomas E. Merchant, Rachel Brennan, Tammy M. Free, Vicki Given, Barrett G. Haik, Carlos Rodriguez-Galindo and Matthew W. Wilson Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity Cancer 118
Article first published online: 19 APR 2012 | DOI: 10.1002/cncr.27563
Topotecan and vincristine is an effective combination for the treatment of advanced intraocular retinoblastoma, and granulocyte colony-stimulating factor treatment alleviates the duration of grade 4 neutropenia. Appropriate topotecan starting doses for patients <1 year of age are specified.
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