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Kelley M. Kidwell, Greg Yothers, Patricia A. Ganz, Stephanie R. Land, Clifford Y. Ko, Reena S. Cecchini, Jacek A. Kopec and Norman Wolmark Long-term neurotoxicity effects of oxaliplatin added to fluorouracil and leucovorin as adjuvant therapy for colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project trials C-07 and LTS-01 Cancer 118

Version of Record online: 8 MAY 2012 | DOI: 10.1002/cncr.27593

In this first long-term (>4 years) assessment of the neurotoxicity effects of oxaliplatin as adjuvant treatment for colon cancer, neurotoxicity scores are compared between treatment groups for those who did and did not receive oxaliplatin. At the long-term endpoint, neurotoxicity scores do not differ clinically between treatment groups, but the specific effects of numbness and tingling of the hands and feet are elevated significantly for oxaliplatin-treated patients.

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