Ana M. Gonzalez-Angulo, Huiqin Chen, Meghan S. Karuturi, Mariana Chavez-MacGregor, Spyrus Tsavachidis, Funda Meric-Bernstam, Kim-Anh Do, Gabriel N. Hortobagyi, Patricia A. Thompson, Gordon B. Mills, Melissa L. Bondy and George R. Blumenschein Jr Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer Cancer 119
Article first published online: 26 JUN 2012 | DOI: 10.1002/cncr.27608
High copy numbers of either Mesenchymal-Epithelial Transition Factor Gene (MET) or catalytic subunit of phosphoinositide-3-kinase (PIK3CA) were associated with poorer prognostic features and triple receptor-negative disease. Coamplification was frequent. Patients with tumors with a high MET copy number tended to have a worse recurrence-free survival.
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