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Wendy Stock, Jeffrey L. Johnson, Richard M. Stone, Jonathan E. Kolitz, Bayard L. Powell, Meir Wetzler, Peter Westervelt, Guido Marcucci, Daniel J. DeAngelo, James W. Vardiman, Diane McDonnell, Krzysztof Mrózek, Clara D. Bloomfield and Richard A. Larson Dose intensification of daunorubicin and cytarabine during treatment of adult acute lymphoblastic leukemia Cancer 119

Version of Record online: 28 JUN 2012 | DOI: 10.1002/cncr.27617

Dose intensification of daunorubicin and cytarabine during induction and consolidation therapy for adult patients with newly diagnosed acute lymphoblastic leukemia is tolerable but does not result in improved disease-free or overall survival compared with historic controls in Cancer and Leukemia Group B Study 19801. The administration of central nervous system prophylaxis with systemic methotrexate (intrathecal, oral, and intravenous) for central nervous system prophylaxis permits the omission of central nervous system irradiation.

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