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Pietro Quaglino, Nicola Pimpinelli, Emilio Berti, Piergiacomo Calzavara-Pinton, Giuseppe Alfonso Lombardo, Serena Rupoli, Mauro Alaibac, Ugo Bottoni, Angelo Carbone, Paolo Fava, Michele Fimiani, Angela Maria Mamusa, Stefano Titli, Pier Luigi Zinzani, Maria Grazia Bernengo and on behalf of the Gruppo Italiano Linfomi Cutanei (GILC) Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides Cancer 118

Article first published online: 6 JUN 2012 | DOI: 10.1002/cncr.27627

This retrospective study analyzed 1422 patients with classic mycosis fungoides who were diagnosed and followed from 1975 through 2010 in 27 Italian centers. The results demonstrate that tumor-lymph node-metastasis-blood (TNMB) stage influences not only the risk but also the pattern of disease progression and that erythroderma occurs more frequently as an evolution of patch/plaque-stage than tumor-stage disease. Finally, the authors provide a further clinical validation of the recently proposed International Society for Cutaneous Lymphomas and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (ISCL/EORTC) staging system.

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