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Meenu Jain, Lisa Zhang, Mei He, Erin E. Patterson, Naris Nilubol, Antonio T. Fojo, Bharat Joshi, Raj Puri and Electron Kebebew Interleukin-13 receptor alpha2 is a novel therapeutic target for human adrenocortical carcinoma Cancer 118

Version of Record online: 8 MAY 2012 | DOI: 10.1002/cncr.27629

In this study of interleukin-13 receptor alpha2 (IL13Rα2) expression in 134 human adrenocortical tissue samples, IL13Rα2 is overexpressed in 100% of adrenocortical carcinomas. IL13Rα2 also directly regulates cell invasion and proliferation in adrenocortical carcinoma cells and is identified as a novel therapeutic target for human adrenocortical carcinoma using IL-13 Pseudomonas exotoxin, in both in vitro and in vivo models.

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