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Razelle Kurzrock, Sanjay Goel, Jennifer Wheler, David Hong, Siqing Fu, Keyvan Rezai, Sonia K. Morgan-Linnell, Saik Urien, Sridhar Mani, Imran Chaudhary, Mohammed H. Ghalib, Aby Buchbinder, François Lokiec and Mary Mulcahy Safety, pharmacokinetics, and activity of EZN-2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies Cancer 118

Version of Record online: 6 JUN 2012 | DOI: 10.1002/cncr.27647

The authors evaluate the tolerability, pharmacokinetics (PK), and activity of EZN-2208, a water-soluble, polyethylene glycol drug conjugate of SN38 (the active moiety of irinotecan), in adult patients with advanced solid tumors. EZN-2208 was well tolerated and produced stable disease for ≥4 months/unconfirmed partial responses in 7 of 39 heavily pretreated patients (18%) with advanced solid tumors, including those who failed on previous irinotecan therapy.

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