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Moubin Lin, Cathy Eng, Ernest T. Hawk, Maosheng Huang, Jie Lin, Jian Gu, Lee M. Ellis and Xifeng Wu Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma Cancer 118

Version of Record online: 6 JUN 2012 | DOI: 10.1002/cncr.27653

In this study, the authors determine the associations of 48 single nucleotide polymorphisms (SNPs) within ultraconserved elements—highly conserved genomic sequences that harbor critical biologic functions—with recurrence and survival in patients with locally advanced colorectal cancer stratified by stage. Eight individual, significant SNPs are identified in a testing set, 1 of which is validated in a validation set, and a significant cumulative effect of multiple risk genotypes and gene-gene interactions is observed on recurrence.

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