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Georgia M. Beasley, Ketan Sharma, Joyce Wong, Mike Miller, Ryan S. Turley, Michael Lidsky, Melanie Masoud, Mark W. Dewhirst, Paul J. Mosca, Jonathan S. Zager and Douglas S. Tyler A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion Cancer 118

Article first published online: 6 JUN 2012 | DOI: 10.1002/cncr.27676

Although studies of melphalan-based isolated limb infusion (ILI) combine data from upper extremity treatments with data from lower extremity treatments, differences between the 2 may be clinically important. The upper extremity appears to be relatively resistant to the toxic effects of melphalan-based ILI as it is currently performed, suggesting a potential for further optimization of drug dosing for upper extremity ILI.

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