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Jonathan How, Jenna Sykes, Vikas Gupta, Karen W. L. Yee, Aaron D. Schimmer, Andre C. Schuh, Mark D. Minden, Suzanne Kamel-Reid and Joseph M. Brandwein Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia Cancer 118

Article first published online: 26 JUN 2012 | DOI: 10.1002/cncr.27683

In patients with acute myeloid leukemia and intermediate-risk cytogenetics, the white blood cell count at presentation is identified as the only prognostic factor for patients who have mutations in the fms-like tyrosine kinase-3–internal tandem duplication (FLT3-ITD) gene. Correcting for the white blood count, FLT3-ITD allele burden does not correlate with survival.

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