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Joo Ho Lee, Young-Hwa Chung, Jeong A. Kim, Ju Hyun Shim, Danbi Lee, Han Chu Lee, Eun-Soon Shin, Jung Hwan Yoon, Byung Ik Kim, Si Hyun Bae, Kwang Cheol Koh and Neung-Hwa Park Genetic predisposition of hand-foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma Cancer 119

Article first published online: 26 JUN 2012 | DOI: 10.1002/cncr.27705

It has been suggested that Asian patients with hepatocellular carcinoma have increased susceptibility to hand-foot skin reaction (HFSR) related to sorafenib therapy. Differences in the incidence of HFSR may be caused by ethnic differences in genetic polymorphisms of the genes, tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and uridine diphosphate glucuronosyltransferase 1 family-polypeptide A9 (UGT1A9), especially in relation to the expression of serum TNF-α after sorafenib therapy.

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