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Elena Miranda, Paolo Bianchi, Annarita Destro, Emanuela Morenghi, Alberto Malesci, Armando Santoro, Luigi Laghi and Massimo Roncalli Genetic and epigenetic alterations in primary colorectal cancers and related lymph node and liver metastases Cancer 119

Version of Record online: 11 JUL 2012 | DOI: 10.1002/cncr.27722

Prognosis and survival in colorectal cancer are mainly associated with the development of distant metastases rather than the primary tumor itself. A comparison of these alterations between primary tumors and distant metastases demonstrates the amount of molecular heterogeneity during colorectal cancer progression and its influence on clinical decision making; in fact, potential prognostic targets should be evaluated carefully for their heterogeneity in both primary tumors and distant metastases to avoid erroneous misclassification.

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