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Theresa Schwartz, Azadeh Stark, Judy Pang, Baffour Awuah, Celina G. Kleer, Solomon Quayson, Stephanie Kingman, Francis Aitpillah, Francis Abantanga, Evelyn Jiagge, Joseph K. Oppong, Ernest Osei-Bonsu, Iman Martin, Xiaowei Yan, Kathy Toy, Ernest Adjei, Max Wicha and Lisa A. Newman Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women Cancer 119

Article first published online: 28 AUG 2012 | DOI: 10.1002/cncr.27737

Mammary stem cells, as identified by cells expressing the marker aldehyde dehydrogenase 1 (ALDH1), appear to be correlated with malignant transformation and progression of breast tissue into biologically aggressive phenotypes. This study reveals increased expression of ALDH1 in benign and malignant tissue of women from the western sub-Saharan African nation of Ghana, a population known to have higher frequency of triple-negative breast cancer, and ALDH1 expression in the malignant specimens was found to be associated with risk of triple-negative breast cancer.

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