Richard R. Jahan-Tigh, Auris O. Huen, Grace L. Lee, Jenny V. Pozadzides, Ping Liu and Madeleine Duvic Hydrochlorothiazide and cutaneous T cell lymphoma Cancer 119
Article first published online: 5 SEP 2012 | DOI: 10.1002/cncr.27740
Mycosis fungoides and leukemic Sézary syndrome are the most common cutaneous T cell lymphomas, but their etiology remains unknown. After patients were observed with hydrochlorothiazide (HCTZ)-associated cutaneous T cell lymphoma, HCTZ was examined as a putative chronic antigen in a cohort of prospectively staged patients. HCTZ is commonly prescribed and may be a putative antigen in a small subset of early mycosis fungoides patients. Careful drug histories and a trial off medication are warranted.
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