Xiao-Min Yu, TramAnh Phan, Priyesh N. Patel, Renata Jaskula-Sztul and Herbert Chen Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo Cancer 119
Version of Record online: 18 SEP 2012 | DOI: 10.1002/cncr.27742
The extremely poor prognosis of anaplastic thyroid carcinoma reflects the lack of curative therapeutic strategies. This report suggests chrysin as a potential therapy, which activates Notch1 signaling and suppresses anaplastic thyroid carcinoma tumor growth both in vitro and in vivo via apoptosis.
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