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Charles S. Cleeland, Jeff A. Sloan, David Cella, Connie Chen, Amylou C. Dueck, Nora A. Janjan, Astra M. Liepa, Rajiv Mallick, Ann O'Mara, Jay D. Pearson, Yasuhiro Torigoe, Xin Shelley Wang, Loretta A. Williams and Jeanie F. Woodruff Recommendations for including multiple symptoms as endpoints in cancer clinical trials Cancer 119

Version of Record online: 28 AUG 2012 | DOI: 10.1002/cncr.27744

The ASCPRO (Assessing the Symptoms of Cancer Using Patient-Reported Outcomes) Multisymptom Task Force examines the measurement of multiple symptoms as cancer clinical trials outcomes. This report defines a multisymptom outcome; addresses source attribution and the need for a hypothesis-driven, conceptual framework to measure multisymptom outcomes; and recommends methods for using multiple, individual symptom scores or composite scores as outcomes.

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