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David V. Gold, Jochen Gaedcke, B. Michael Ghadimi, Michael Goggins, Ralph H. Hruban, Mengling Liu, Guy Newsome and David M. Goldenberg PAM4 enzyme immunoassay alone and in combination with CA 19-9 for the detection of pancreatic adenocarcinoma Cancer 119

Version of Record online: 16 AUG 2012 | DOI: 10.1002/cncr.27762

The monoclonal antibody PAM4 has high specificity for pancreatic ductal adenocarcinoma (PDAC), as well as its precursor lesions, but has not been found to be reactive with normal and benign pancreatic tissues. In the current study, the authors report that a combined PAM4 and carbohydrate antigen (CA) 19-9 biomarker serum assay can provide high sensitivity for the detection of early stage PDAC with high diagnostic accuracy.

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