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Paul F. Pinsky, Amanda Black, Robert Grubb, E. David Crawford, Gerald Andriole, Ian Thompson and Howard Parnes Projecting prostate cancer mortality in the PCPT and REDUCE chemoprevention trials Cancer 119

Article first published online: 14 AUG 2012 | DOI: 10.1002/cncr.27774

The Prostate Cancer Prevention Trial (PCPT) and Reduction by Dutasteride of Prostate Cancer Events (REDUCE) chemoprevention trials demonstrated substantial overall reductions in prostate cancer incidence but hints of an increased rate of high-grade disease. A projection of the mortality outcomes of these trials suggests a possibly modest mortality benefit for these agents and, at worst, a small mortality excess.

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