Peter E. Zage, Natalie Sirisaengtaksin, Yin Liu, Monica Gireud, Brandon S. Brown, Shana Palla, Kristen N. Richards, Dennis P. M. Hughes and Andrew J. Bean UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors Cancer 119
Version of Record online: 18 SEP 2012 | DOI: 10.1002/cncr.27785
The authors report an association between UBE4B gene expression and outcomes of patients with neuroblastoma and demonstrate that levels of UBE4B influence neuroblastoma tumor cell proliferation, EGFR degradation, and response to EGFR inhibition. These results suggest that UBE4B-mediated growth factor receptor trafficking may contribute to the poor prognosis of patients who have neuroblastoma with chromosome 1p36 deletions and that UBE4B expression may be a marker that can predict responses of neuroblastoma tumors to treatment.
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