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Ruo-Yu Shi, Xin-Rong Yang, Qiu-Jin Shen, Liu-Xiao Yang, Yang Xu, Shuang-Jian Qiu, Yun-Fan Sun, Xin Zhang, Zheng Wang, Kai Zhu, Wen-Xin Qin, Zhao-You Tang, Jia Fan and Jian Zhou High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery Cancer 119

Article first published online: 6 NOV 2012 | DOI: 10.1002/cncr.27788

Dickkopf-related protein 1 (DKK1) enhances intrahepatic cholangiocarcinoma invasion and promotes lymph node metastasis through the induction of matrix metalloproteinase 9 and vascular endothelial growth factor C. DKK1 may be a novel prognostic biomarker and a potential therapeutic target for intrahepatic cholangiocarcinoma.

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