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E. Shelley Hwang, Daphne Y. Lichtensztajn, Scarlett Lin Gomez, Barbara Fowble and Christina A. Clarke Survival after lumpectomy and mastectomy for early stage invasive breast cancer Cancer 119

Version of Record online: 28 JAN 2013 | DOI: 10.1002/cncr.27795

Among patients diagnosed with early-stage breast cancer in a large statewide cancer registry, breast-conserving therapy was associated with improved disease-specific survival compared to mastectomy; this benefit was greater among women age ≥ 50 with hormone receptor (HR)-positive disease (hazard ratio =–0.86, 95% confidence interval =–0.82-0.91) than among women age < 50 with HR-negative disease (hazard ratio =–0.88, 95% confidence interval =–0.79-0.98). These data provide confidence that breast-conserving therapy remains an effective alternative to mastectomy for early-stage disease, regardless of age or HR status.

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