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Xiao-Wei Wang, Blandine Boisselier, Marta Rossetto, Yannick Marie, Ahmed Idbaih, Karima Mokhtari, Konstantinos Gousias, Khê Hoang-Xuan, Jean-Yves Delattre, Matthias Simon, Marianne Labussière and Marc Sanson Prognostic impact of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in malignant gliomas Cancer 119

Article first published online: 26 NOV 2012 | DOI: 10.1002/cncr.27798

A single-nucleotide polymorphism (SNP) located on codon 105 of the isocitrate dehydrogenase 1 (IDH1) gene (reference SNP rs11554137) is analyzed in 3 independent series of patients with gliomas. The SNP rs11554137 is independent of the occurrence of somatic mutation on IDH1 codon 132, but, per se, has a prognostic impact in malignant gliomas.

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