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Maurizio Martini, Tonia Cenci, Giorgio Quintino D'Alessandris, Valeriana Cesarini, Alessandra Cocomazzi, Lucia Ricci-Vitiani, Ruggero De Maria, Roberto Pallini and Luigi Maria Larocca Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis Cancer 119

Version of Record online: 6 NOV 2012 | DOI: 10.1002/cncr.27821

Id4 (inhibitor of DNA binding/differentiation type 4) epigenetic silencing identified a subgroup of glioblastoma with a favorable clinical outcome when treated with surgery followed by adjuvant radiotherapy and temozolomide. This effect may be due to involvement of Id4 in the MGP (matrix GLA protein)-mediated neoangiogenesis.

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