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Felice Pasini, Giovanni de Manzoni, Andrea Zanoni, Antonio Grandinetti, Carlo Capirci, Michele Pavarana, Anna Tomezzoli, Domenico Rubello and Claudio Cordiano Neoadjuvant therapy with weekly docetaxel and cisplatin, 5-fluorouracil continuous infusion, and concurrent radiotherapy in patients with locally advanced esophageal cancer produced a high percentage of long-lasting pathological complete response Cancer 119

Version of Record online: 16 NOV 2012 | DOI: 10.1002/cncr.27822

This phase 2 study sought to define the pathological response rate of a neoadjuvant schedule including weekly docetaxel and cisplatin, continuous infusion of fluorouracil, and concomitant radiotherapy in untreated stage II-III adenocarcinoma and squamous cell carcinoma of mid-distal thoracic esophagus. Results show that this intensive weekly schedule produced a high pathological response rate, and responders had high and long-term durable survival rates.

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