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Roberto Crocchiolo, Benjamin Esterni, Luca Castagna, Sabine Fürst, Jean El-Cheikh, Raynier Devillier, Angela Granata, Claire Oudin, Boris Calmels, Christian Chabannon, Réda Bouabdallah, Norbert Vey and Didier Blaise Two days of antithymocyte globulin are associated with a reduced incidence of acute and chronic graft-versus-host disease in reduced-intensity conditioning transplantation for hematologic diseases Cancer 119

Article first published online: 23 OCT 2012 | DOI: 10.1002/cncr.27858

The use of antithymocyte globulin (ATG) in the conditioning regimen at a dose of 5 mg/kg significantly reduces the incidence and severity of acute and chronic graft-versus-host disease compared with an ATG dose of 2.5 mg/kg, among patients undergoing reduced-intensity conditioning transplantation for hematologic diseases without any evidence of impaired disease control. This conditioning represents a step forward in the optimization of a preparative regimen for reduced-intensity conditioning transplantation.

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