Marjun P. Duldulao, Wendy Lee, Rebecca A. Nelson, Joyce Ho, Maithao Le, Zhenbin Chen, Wenyan Li, Joseph Kim and Julio Garcia-Aguilar Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer Cancer 119
Version of Record online: 23 OCT 2012 | DOI: 10.1002/cncr.27862
Specific polymorphisms in the genes x-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), xeroderma pigmentosum group D (XPD), and tumor protein 53 (TP53) are associated with increased toxicity to neoadjuvant chemoradiation therapy (NT) in rectal cancer. Screening for these polymorphisms may help tailor treatment for patients by selecting therapies with the lowest risk of toxicity, thus increasing patient compliance.
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