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Jessica E. Cott Chubiz, Janie M. Lee, Michael E. Gilmore, Chung Y. Kong, Kathryn P. Lowry, Elkan F. Halpern, Pamela M. McMahon, Paula D, Ryan and G. Scott Gazelle Cost-effectiveness of alternating magnetic resonance imaging and digital mammography screening in BRCA1 and BRCA2 gene mutation carriers Cancer 119

Article first published online: 26 NOV 2012 | DOI: 10.1002/cncr.27864

A computer model was used to simulate the health outcomes and costs of dual-modality screening strategies for women with BRCA gene mutations. The results indicate that screening with digital mammography and magnetic resonance imaging at alternating 6-month intervals starting at age 30 years provides life-expectancy gains and breast cancer mortality reduction, and is the least costly approach for implementing current screening guidelines in both BRCA1 and BRCA2 mutation carriers.

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