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Rebecca J. Leeman-Neill, Alina V. Brenner, Mark P. Little, Tetiana I. Bogdanova, Maureen Hatch, Liudmyla Y. Zurnadzy, Kiyohiko Mabuchi, Mykola D. Tronko and Yuri E. Nikiforov RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics Cancer 119

Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.27893

This study of papillary thyroid carcinomas in populations exposed to the 1986 accident in Chernobyl, Ukraine, provides the first documentation of PAX8/PPARγ rearrangements in post-Chernobyl thyroid cancer; demonstrates a link between chromosomal rearrangements, but not point mutations, and individual iodine-131 dose received; and points to a possible role of iodine deficiency in generation of RET/PTC rearrangements in these patients.

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