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Baoxiang Guan, Hao Li, Zhengduo Yang, Ashraful Hoque and Xiaochun Xu Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts Cancer 119

Version of Record online: 20 DEC 2012 | DOI: 10.1002/cncr.27910

Farnesoid X receptor (FXR) is overexpressed in esophageal adenocarcinoma tissues, and inhibition of FXR suppresses tumor cell viability by inducing apoptosis in vitro and reduces tumor formation and growth in nude mouse xenografts. FXR also mediates the effects of bile acids on the expression of cell growth-related genes in esophageal cancer cells.

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