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Bree R. Eaton, Mark W. McDonald, Sungjin Kim, Robert B. Marcus Jr., Anna L. Sutter, Zhengjia Chen and Natia Esiashvili Radiation therapy target volume reduction in pediatric rhabdomyosarcoma Cancer 119

Article first published online: 27 DEC 2012 | DOI: 10.1002/cncr.27934

In this review of 55 children with non-metastatic rhabdomyosarcoma, 28 patients (51%) received a radiation therapy cone-down boost with a median relative reduction in the high-dose treatment volume of 56% (range, 5%-91%). The local control rate was 91% with no recognized detriment to the receipt of reduced volume RT; however, in the subset of patients with parameningeal rhabdomyosarcoma and intracranial tumor extension, 4 patients (30%) who received reduced volume RT experienced leptomeningeal failure as their first site of disease progression.

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