Nils Kroeger, Tobias Klatte, Karim Chamie, P. Nagesh Rao, Frédéric D. Birkhäuser, Geoffrey A. Sonn, Joseph Riss, Fairooz F. Kabbinavar, Arie S. Belldegrun and Allan J. Pantuck Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma Cancer 119
Article first published online: 18 JAN 2013 | DOI: 10.1002/cncr.27947
In patients with clear cell renal cell carcinoma, loss of the von Hippel-Lindau (VHL) gene is associated with more favorable pathologic features and with improved recurrence-free and cancer-specific survival, whereas loss of the hypoxia-inducible factor 1α (HIF-1α) gene is associated with worse recurrence-free and cancer-specific survival. Combined loss of chromosome 3p/14q is a strong predictor of disease recurrence in patients with low-stage (pathologic T1) renal cell carcinoma, supporting the hypothesis that HIF-1α functions as a tumor suppressor gene in clear cell renal cell carcinoma.
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