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Brian O'Sullivan, Anthony M. Griffin, Colleen I. Dickie, Michael B. Sharpe, Peter W. M. Chung, Charles N. Catton, Peter C. Ferguson, Jay S. Wunder, Benjamin M. Deheshi, Lawrence M. White, Rita A. Kandel, David A. Jaffray and Robert S. Bell Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma Cancer 119

Article first published online: 19 FEB 2013 | DOI: 10.1002/cncr.27951

The results of this prospective trial indicate that image-guided intensity-modulated radiotherapy appears to reduce the risk and severity of wound complications by reducing dose to tissues required for wound closure following soft tissue sarcoma resection. Moreover, the dose to bone and unaffected musculature is also apparently reduced, leading to improved limb function measures with no bone fractures.

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