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Maylee Hsu, Motoko Sasaki, Saya Igarashi, Yasunori Sato and Yasuni Nakanuma KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas Cancer 119

Article first published online: 18 JAN 2013 | DOI: 10.1002/cncr.27955

Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) occur as an early molecular event during the progression of biliary intraepithelial neoplasia to intrahepatic cholangiocarcinoma. Biliary intraepithelial neoplasia may arise from large bile ducts and peribiliary glands with KRAS mutations in patients with hepatolithiasis.

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