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Jeffrey S. Weber, Reinhard Dummer, Veerle de Pril, Celeste Lebbé, F. Stephen Hodi and for the MDX010-20 Investigators Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab Cancer 119

Version of Record online: 7 FEB 2013 | DOI: 10.1002/cncr.27969

In the phase 3 MDX010-20 trial, treatment with ipilimumab resulted in a characteristic spectrum of adverse events of special interest, consistent with its immune-based mechanism of action. Most ipilimumab-associated adverse events developed within 12 weeks of initial dosing and could be managed using published algorithms.

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