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Liana D. Castel, Katherine E. Hartmann, Ingrid A. Mayer, Benjamin R. Saville, JoAnn Alvarez, Chad S. Boomershine, Vandana G. Abramson, A. Bapsi Chakravarthy, Debra L. Friedman and David F. Cella Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort Cancer 119

Article first published online: 10 APR 2013 | DOI: 10.1002/cncr.28016

In postmenopausal women initiating aromatase inhibitors (AI) for adjuvant hormonal treatment of early-stage breast cancer, arthralgia (joint pain) trajectories diverge in comparison with the background rate at 6 weeks following AI initiation, and arthralgia worsens over a year following the divergence. Menopausal symptom severity and existing joint conditions at AI initiation should be assessed in women initiating AI to identify patients at risk for later new or exacerbating arthralgia.

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