Dana M. Roque, Stefania Bellone, Diana P. English, Natalia Buza, Emiliano Cocco, Sara Gasparrini, Ileana Bortolomai, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Thomas J. Rutherford, Peter E. Schwartz and Alessandro D. Santin Tubulin-β-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones Cancer 119
Article first published online: 12 APR 2013 | DOI: 10.1002/cncr.28017
Uterine serous carcinomas represent an aggressive variant of endometrial cancer that overexpress tubulin-β-III relative to ovarian serous carcinomas. Among patients with advanced-stage disease, tubulin-β-III overexpression by quantitative real-time polymerase chain reaction or immunohistochemistry stratifies patients who are simultaneously at risk of reduced overall survival after platinum/taxane combination chemotherapy and likely to respond to epothilones.
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