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Luis O. Olivatto, Fernando M. Vieira, Bruno V. Pereira, Ana P. Victorino, Marcos Bezerra, Carlos M. Araujo, Felipe Erlich, Lilian Faroni, Leonaldson Castro, Edward C. Lusis, Alessandra Marins and Carlos Gil Ferreira Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma Cancer 119

Article first published online: 14 MAY 2013 | DOI: 10.1002/cncr.28045

This is the first report of an anti–epidermal growth factor receptor monoclonal antibody used in combination with chemoradiation in locally advanced anal canal carcinoma. Cetuximab could not be integrated with pelvic chemoradiation based on 5-fluorouracil and cisplatin, due to the high toxicity rate.

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